This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001142) is described by MIBiG as an example of the following biosynthetic class, NRP (non-ribosomal peptide). It includes a member of the tryptoquialanine biosynthetic gene cluster from Penicillium aethiopicum [[cite:PUB00099397]]. This family appears to be predominantly found in fungi.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00099397":{"PMID":21299212,"ISBN":null,"volume":"133","issue":"8","year":2011,"title":"Fungal indole alkaloid biosynthesis: genetic and biochemical investigation of the tryptoquialanine pathway in Penicillium aethiopicum.","URL":null,"raw_pages":"2729-41","medline_journal":"J Am Chem Soc","ISO_journal":"J Am Chem Soc","authors":["Gao X","Chooi YH","Ames BD","Wang P","Walsh CT","Tang Y."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":19,"pathways":0,"proteins":19,"proteomes":18,"sets":0,"structural_models":{"alphafold":17},"structures":0,"taxa":38},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":3,"alignment:full":16},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}