This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001856) is described by MIBiG as an example of the following biosynthetic class, polyketide. It includes a member from the caniferolide A biosynthetic gene cluster from Streptomyces caniferus [[cite:PUB00099460]]. This family appears to be predominantly found in Actinobacteria.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00099460":{"PMID":30806648,"ISBN":null,"volume":"17","issue":"11","year":2019,"title":"Structure elucidation and biosynthetic gene cluster analysis of caniferolides A-D, new bioactive 36-membered macrolides from the marine-derived Streptomyces caniferus CA-271066.","URL":null,"raw_pages":"2954-2971","medline_journal":"Org Biomol Chem","ISO_journal":"Org Biomol Chem","authors":["Perez-Victoria I","Oves-Costales D","Lacret R","Martin J","Sanchez-Hidalgo M","Diaz C","Cautain B","Vicente F","Genilloud O","Reyes F."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":227,"pathways":0,"proteins":226,"proteomes":220,"sets":0,"structural_models":{"alphafold":91},"structures":0,"taxa":252},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":32,"alignment:full":102},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}