This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001782) is described by MIBiG as an example of the following biosynthetic class, other (unspecified). It includes a member from the spiroindimicin A biosynthetic gene cluster from Streptomyces sp. SCSIO 03032 [[cite:PUB00099387]]. This family appears to be predominantly found in Actinobacteria.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00099387":{"PMID":28620687,"ISBN":null,"volume":"101","issue":"15","year":2017,"title":"Identification and characterization of a biosynthetic gene cluster for tryptophan dimers in deep sea-derived Streptomyces sp. SCSIO 03032.","URL":null,"raw_pages":"6123-6136","medline_journal":"Appl Microbiol Biotechnol","ISO_journal":"Appl Microbiol Biotechnol","authors":["Ma L","Zhang W","Zhu Y","Zhang G","Zhang H","Zhang Q","Zhang L","Yuan C","Zhang C."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":3,"interactions":0,"matches":401,"pathways":0,"proteins":370,"proteomes":365,"sets":0,"structural_models":{"alphafold":152},"structures":0,"taxa":404},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":29,"alignment:full":176},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}