This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001448) is described by MIBiG as an example of the following biosynthetic class, NRP (non-ribosomal peptide). It includes a member from the malacidin A biosynthetic gene cluster from uncultured bacterium [[cite:PUB00099471]]. This family appears to be predominantly found in bacteria.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00099471":{"PMID":29434326,"ISBN":null,"volume":"3","issue":"4","year":2018,"title":"Culture-independent discovery of the malacidins as calcium-dependent antibiotics with activity against multidrug-resistant Gram-positive pathogens.","URL":null,"raw_pages":"415-422","medline_journal":"Nat Microbiol","ISO_journal":"Nat Microbiol","authors":["Hover BM","Kim SH","Katz M","Charlop-Powers Z","Owen JG","Ternei MA","Maniko J","Estrela AB","Molina H","Park S","Perlin DS","Brady SF."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":144,"pathways":0,"proteins":144,"proteomes":140,"sets":0,"structural_models":{"alphafold":76},"structures":0,"taxa":320},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":56,"alignment:full":64},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}