This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC00001940) is described by MIBiG as an example of the following biosynthetic class, polyketide. It includes a member from the pyxidicycline A biosynthetic gene cluster from Pyxidicoccus fallax [[cite:PUB00099476]]. This family appears to be predominantly found in bacteria.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00099476":{"PMID":29910943,"ISBN":null,"volume":"9","issue":"21","year":2018,"title":"Self-resistance guided genome mining uncovers new topoisomerase inhibitors from myxobacteria.","URL":null,"raw_pages":"4898-4908","medline_journal":"Chem Sci","ISO_journal":"Chem Sci","authors":["Panter F","Krug D","Baumann S","Muller R."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":4,"interactions":0,"matches":107,"pathways":0,"proteins":103,"proteomes":55,"sets":0,"structural_models":{"alphafold":74},"structures":0,"taxa":154},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":7,"alignment:full":57},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}