This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001709) is described by MIBiG as an example of the following biosynthetic class, polyketide. It includes a member from the nystatin biosynthetic gene cluster from Streptomyces albulus [[cite:PUB00098984]]. This family appears to be predominantly found in Actinobacteria.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00098984":{"PMID":30405594,"ISBN":null,"volume":"9","issue":null,"year":2018,"title":"Identification of wysPII as an Activator of Morphological Development in Streptomyces albulus CK-15.","URL":null,"raw_pages":"2550","medline_journal":"Front Microbiol","ISO_journal":"Front Microbiol","authors":["Liu B","Ge B","Ma J","Wei Q","Khan AA","Shi L","Zhang K."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":6,"interactions":0,"matches":326,"pathways":0,"proteins":326,"proteomes":221,"sets":0,"structural_models":{"alphafold":92},"structures":0,"taxa":255},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":16,"alignment:full":103},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}