This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001070) is described by MIBiG as an example of the following biosynthetic classes, NRP (non-ribosomal peptide) and polyketide. It includes a member from the kirromycin biosynthetic gene cluster from Streptomyces collinus Tu 365 [[cite:PUB00098988],[cite:PUB00098989]]. This family appears to be predominantly found in Actinobacteria.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00098988":{"PMID":4373734,"ISBN":null,"volume":"71","issue":"12","year":1974,"title":"Kirromycin, an inhibitor of protein biosynthesis that acts on elongation factor Tu.","URL":null,"raw_pages":"4910-4","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc Natl Acad Sci U S A","authors":["Wolf H","Chinali G","Parmeggiani A."],"DOI_URL":null},"PUB00098989":{"PMID":18291322,"ISBN":null,"volume":"15","issue":"2","year":2008,"title":"Molecular analysis of the kirromycin biosynthetic gene cluster revealed beta-alanine as precursor of the pyridone moiety.","URL":null,"raw_pages":"175-88","medline_journal":"Chem Biol","ISO_journal":"Chem Biol","authors":["Weber T","Laiple KJ","Pross EK","Textor A","Grond S","Welzel K","Pelzer S","Vente A","Wohlleben W."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":757,"pathways":0,"proteins":757,"proteomes":744,"sets":0,"structural_models":{"alphafold":384},"structures":0,"taxa":903},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":47,"alignment:full":345},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}