This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001943) is described by MIBiG as an example of the following biosynthetic class, NRP (non-ribosomal peptide). It includes a member from the vioprolides A biosynthetic gene cluster from Cystobacter sp. [[cite:PUB00098917]]. This family appears to be predominantly found in bacteria.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00098917":{"PMID":29694699,"ISBN":null,"volume":"57","issue":"28","year":2018,"title":"Biosynthesis and Heterologous Production of Vioprolides: Rational Biosynthetic Engineering and Unprecedented 4-Methylazetidinecarboxylic Acid Formation.","URL":null,"raw_pages":"8754-8759","medline_journal":"Angew Chem Int Ed Engl","ISO_journal":"Angew Chem Int Ed Engl","authors":["Yan F","Auerbach D","Chai Y","Keller L","Tu Q","Huttel S","Glemser A","Grab HA","Bach T","Zhang Y","Muller R."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":68,"pathways":0,"proteins":68,"proteomes":37,"sets":0,"structural_models":{"alphafold":45,"bfvd":0},"structures":0,"taxa":147},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":7,"alignment:full":21},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}