{"metadata":{"accession":"PF19701","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR045679","hierarchy":null,"name":{"name":"Family of unknown function (DUF6199)","short":"DUF6199"},"description":[{"text":"<p>This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000087) is described by MIBiG as an example of the following biosynthetic class, polyketide. It includes a member from the lasalocid biosynthetic gene cluster from Streptomyces lasaliensis [[cite:PUB00098916]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00098916":{"PMID":19025863,"ISBN":null,"volume":"9","issue":"18","year":2008,"title":"Analysis of specific mutants in the lasalocid gene cluster: evidence for enzymatic catalysis of a disfavoured polyether ring closure.","URL":null,"raw_pages":"2967-75","medline_journal":"Chembiochem","ISO_journal":"Chembiochem","authors":["Smith L","Hong H","Spencer JB","Leadlay PF."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":3,"interactions":0,"matches":996,"pathways":0,"proteins":996,"proteomes":769,"sets":0,"structural_models":{"alphafold":653},"structures":0,"taxa":1223},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":293,"alignment:full":523},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}