This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001381) is described by MIBiG as an example of the following biosynthetic class, polyketide. It includes a member from the brasilinolide A biosynthetic gene cluster from Nocardia terpenica [[cite:PUB00098914]]. This family appears to be predominantly found in bacteria.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00098914":{"PMID":26754528,"ISBN":null,"volume":"14","issue":"6","year":2016,"title":"Target-specific identification and characterization of the putative gene cluster for brasilinolide biosynthesis revealing the mechanistic insights and combinatorial synthetic utility of 2-deoxy-l-fucose biosynthetic enzymes.","URL":null,"raw_pages":"1988-2006","medline_journal":"Org Biomol Chem","ISO_journal":"Org Biomol Chem","authors":["Chiu HT","Weng CP","Lin YC","Chen KH."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":118,"pathways":0,"proteins":118,"proteomes":117,"sets":0,"structural_models":{"alphafold":61},"structures":0,"taxa":276},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":25,"alignment:full":48},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}