This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001597) is described by MIBiG as an example of the following biosynthetic class, polyketide. It includes a member from the fluvirucin B2 biosynthetic gene cluster from Actinomadura fulva subsp. indica [[cite:PUB00098915]]. This family appears to be predominantly found in bacteria.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00098915":{"PMID":26818633,"ISBN":null,"volume":"80","issue":"5","year":2016,"title":"Identification of the Fluvirucin B2 (Sch 38518) Biosynthetic Gene Cluster from Actinomadura fulva subsp. indica ATCC 53714: substrate Specificity of the β-Amino Acid Selective Adenylating Enzyme FlvN.","URL":null,"raw_pages":"935-41","medline_journal":"Biosci Biotechnol Biochem","ISO_journal":"Biosci Biotechnol Biochem","authors":["Miyanaga A","Hayakawa Y","Numakura M","Hashimoto J","Teruya K","Hirano T","Shin-Ya K","Kudo F","Eguchi T."],"DOI_URL":null}},"set_info":{"accession":"CL0631","name":"YgaC_TfoX-N"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":5,"interactions":0,"matches":1037,"pathways":0,"proteins":1037,"proteomes":1018,"sets":1,"structural_models":{"alphafold":598},"structures":0,"taxa":1595},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":125,"alignment:full":472},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}