This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0002014) is described by MIBiG as an example of the following biosynthetic classes, polyketide and NRP (non-ribosomal peptide). It includes a member of the pepticinnamin E biosynthetic gene cluster from Actinobacteria bacterium OK006 [[cite:PUB00098920]]. This family appears to be predominantly found in Actinobacteria.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00098920":{"PMID":30694017,"ISBN":null,"volume":"20","issue":"11","year":2019,"title":"Targeted Rediscovery and Biosynthesis of the Farnesyl-Transferase Inhibitor Pepticinnamin E.","URL":null,"raw_pages":"1387-1393","medline_journal":"Chembiochem","ISO_journal":"Chembiochem","authors":["Santa Maria KC","Chan AN","O'Neill EM","Li B."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":6,"interactions":0,"matches":1379,"pathways":0,"proteins":1379,"proteomes":1060,"sets":0,"structural_models":{"alphafold":640},"structures":0,"taxa":1250},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":213,"alignment:full":615},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}