This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001215) is described by MIBiG as an example of the following biosynthetic class, NRP (non-ribosomal peptide). It includes a member from the conglobatin biosynthetic gene cluster from Streptomyces conglobatus [[cite:PUB00099436]]. This family appears to be predominantly found in Actinobacteria.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00099436":{"PMID":26091168,"ISBN":null,"volume":"22","issue":"6","year":2015,"title":"Iterative Mechanism of Macrodiolide Formation in the Anticancer Compound Conglobatin.","URL":null,"raw_pages":"745-54","medline_journal":"Chem Biol","ISO_journal":"Chem Biol","authors":["Zhou Y","Murphy AC","Samborskyy M","Prediger P","Dias LC","Leadlay PF."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":362,"pathways":0,"proteins":362,"proteomes":353,"sets":0,"structural_models":{"alphafold":205},"structures":0,"taxa":469},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":27,"alignment:full":164},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}