This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000990) is described by MIBiG as an example of the following biosynthetic class, polyketide. It includes a member from the epothilone biosynthetic gene cluster from Sorangium cellulosum [[cite:PUB00015753]]. This family appears to be predominantly found in Proteobacteria.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00015753":{"PMID":10662695,"ISBN":null,"volume":"7","issue":"2","year":2000,"title":"The biosynthetic gene cluster for the microtubule-stabilizing agents epothilones A and B from Sorangium cellulosum So ce90.","URL":null,"raw_pages":"97-109","medline_journal":"Chem Biol","ISO_journal":"Chem. Biol.","authors":["Molnar I","Schupp T","Ono M","Zirkle R","Milnamow M","Nowak-Thompson B","Engel N","Toupet C","Stratmann A","Cyr DD","Gorlach J","Mayo JM","Hu A","Goff S","Schmid J","Ligon JM."],"DOI_URL":"http://dx.doi.org/10.1016/S1074-5521(00)00075-2"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":53,"pathways":0,"proteins":53,"proteomes":29,"sets":0,"structural_models":{"alphafold":30},"structures":0,"taxa":69},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":9,"alignment:full":21},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}