This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001726) is described by MIBiG as an example of the following biosynthetic classes, NRP (non-ribosomal peptide) and polyketide. It includes a member from the pactamides biosynthetic gene cluster from Streptomyces pactum [[cite:PUB00098964]]. This family appears to be predominantly found in Actinobacteria.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00098964":{"PMID":28451290,"ISBN":null,"volume":"8","issue":"2","year":2017,"title":"Activation and characterization of a cryptic gene cluster reveals a cyclization cascade for polycyclic tetramate macrolactams.","URL":null,"raw_pages":"1607-1612","medline_journal":"Chem Sci","ISO_journal":"Chem Sci","authors":["Saha S","Zhang W","Zhang G","Zhu Y","Chen Y","Liu W","Yuan C","Zhang Q","Zhang H","Zhang L","Zhang W","Zhang C."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":212,"pathways":0,"proteins":212,"proteomes":201,"sets":0,"structural_models":{"alphafold":91},"structures":0,"taxa":320},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":52,"alignment:full":103},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}