This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001774) is described by MIBiG as an example of the following biosynthetic class, other (unspecified). It includes a member from the spicamycin biosynthetic gene cluster from Streptomyces fimbriatus [[cite:PUB00098963]]. This family appears to be predominantly found in Actinobacteria.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00098963":{"PMID":29483275,"ISBN":null,"volume":"115","issue":"11","year":2018,"title":"d-Sedoheptulose-7-phosphate is a common precursor for the heptoses of septacidin and hygromycin B.","URL":null,"raw_pages":"2818-2823","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc Natl Acad Sci U S A","authors":["Tang W","Guo Z","Cao Z","Wang M","Li P","Meng X","Zhao X","Xie Z","Wang W","Zhou A","Lou C","Chen Y."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":129,"pathways":0,"proteins":127,"proteomes":120,"sets":0,"structural_models":{"alphafold":56},"structures":0,"taxa":187},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":39,"alignment:full":59},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}