This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001091) is described by MIBiG as an example of the following biosynthetic classes, NRP (non-ribosomal peptide) and polyketide. It includes a member from the corallopyronin biosynthetic gene cluster from Corallococcus coralloides [[cite:PUB00098961]]. This family appears to be predominantly found in proteobacteria.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00098961":{"PMID":20503218,"ISBN":null,"volume":"11","issue":"9","year":2010,"title":"Biosynthesis of the myxobacterial antibiotic corallopyronin A.","URL":null,"raw_pages":"1253-65","medline_journal":"Chembiochem","ISO_journal":"Chembiochem","authors":["Erol O","Schaberle TF","Schmitz A","Rachid S","Gurgui C","El Omari M","Lohr F","Kehraus S","Piel J","Muller R","Konig GM."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":4,"interactions":0,"matches":199,"pathways":0,"proteins":198,"proteomes":181,"sets":0,"structural_models":{"alphafold":152},"structures":0,"taxa":417},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":33,"alignment:full":128},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}