This entry represents the C-terminal domain of a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000360) is described by MIBiG as an example of the following biosynthetic class, NRP (non-ribosomal peptide). It includes a member from the GE81112 biosynthetic gene cluster from Streptomyces sp. L-49973 and appears to be predominantly found in Actinobacteria [[cite:PUB00074314]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00074314":{"PMID":20710026,"ISBN":null,"volume":"285","issue":"43","year":2010,"title":"Insights into an unusual nonribosomal peptide synthetase biosynthesis: identification and characterization of the GE81112 biosynthetic gene cluster.","URL":null,"raw_pages":"32710-9","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Binz TM","Maffioli SI","Sosio M","Donadio S","Muller R."],"DOI_URL":"http://dx.doi.org/10.1074/jbc.M110.146803"}},"set_info":{"accession":"CL0961","name":"TsiV_TsiT-like"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":3,"interactions":0,"matches":745,"pathways":0,"proteins":741,"proteomes":531,"sets":1,"structural_models":{"alphafold":335},"structures":0,"taxa":672},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":70,"alignment:full":314},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}