{"metadata":{"accession":"PF19673","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR046174","hierarchy":null,"name":{"name":"Family of unknown function (DUF6176)","short":"DUF6176"},"description":[{"text":"<p>This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000198) is described by MIBiG as an example of the following biosynthetic classes, polyketide and saccharide. It  includes a member from the arenimycin A biosynthetic gene cluster  from Salinispora arenicola CNB527 [[cite:PUB00099432],[cite:PUB00099413]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00099432":{"PMID":24191063,"ISBN":null,"volume":"110","issue":"47","year":2013,"title":"Glycogenomics as a mass spectrometry-guided genome-mining method for microbial glycosylated molecules.","URL":null,"raw_pages":"E4407-16","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc Natl Acad Sci U S A","authors":["Kersten RD","Ziemert N","Gonzalez DJ","Duggan BM","Nizet V","Dorrestein PC","Moore BS."],"DOI_URL":null},"PUB00099413":{"PMID":19927167,"ISBN":null,"volume":"63","issue":"1","year":2010,"title":"Arenimycin, an antibiotic effective against rifampin- and methicillin-resistant Staphylococcus aureus from the marine actinomycete Salinispora arenicola.","URL":null,"raw_pages":"37-9","medline_journal":"J Antibiot (Tokyo)","ISO_journal":"J Antibiot (Tokyo)","authors":["Asolkar RN","Kirkland TN","Jensen PR","Fenical W."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":3,"interactions":0,"matches":550,"pathways":0,"proteins":550,"proteomes":505,"sets":0,"structural_models":{"alphafold":360},"structures":0,"taxa":995},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":96,"alignment:full":239},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}