{"metadata":{"accession":"PF19650","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR046151","hierarchy":null,"name":{"name":"Family of unknown function (DUF6153)","short":"DUF6153"},"description":[{"text":"<p>This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001435) is described by MIBiG as an example of the following biosynthetic classes, polyketide and NRP (non-ribosomal  peptide). It includes a member from the ikarugamycin biosynthetic  gene cluster from Streptomyces sp. ZJ306 and appears to be  predominantly found in Actinobacteria [[cite:PUB00099375],[cite:PUB00099373]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00099375":{"PMID":24519911,"ISBN":null,"volume":"53","issue":"11","year":2014,"title":"Heterologous reconstitution of ikarugamycin biosynthesis in E. coli.","URL":null,"raw_pages":"3011-4","medline_journal":"Angew Chem Int Ed Engl","ISO_journal":"Angew Chem Int Ed Engl","authors":["Antosch J","Schaefers F","Gulder TA."],"DOI_URL":null},"PUB00099373":{"PMID":24706593,"ISBN":null,"volume":"53","issue":"19","year":2014,"title":"Mechanistic insights into polycycle formation by reductive cyclization in ikarugamycin biosynthesis.","URL":null,"raw_pages":"4840-4","medline_journal":"Angew Chem Int Ed Engl","ISO_journal":"Angew Chem Int Ed Engl","authors":["Zhang G","Zhang W","Zhang Q","Shi T","Ma L","Zhu Y","Li S","Zhang H","Zhao YL","Shi R","Zhang C."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":1297,"pathways":0,"proteins":1296,"proteomes":1078,"sets":0,"structural_models":{"alphafold":619},"structures":0,"taxa":1335},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":81,"alignment:full":611},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}