{"metadata":{"accession":"PF19631","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR045608","hierarchy":null,"name":{"name":"Trypsin-co-occurring domain 2","short":"Trypco2"},"description":[{"text":"<p>Trypsin-like peptidase effector in the classical NTP-dependent ternary system (vWA-MoxR-VMAP) frequently co-occurs with one of two proteins (Trypco1 or Trypco2) which are mostly mutually exclusively [[cite:PUB00098776]]. This entry also includes a member of a biosynthetic gene cluster (BGC).  This BGC (BGC0000949) is described by MIBiG as an example of the following biosynthetic class, NRP (non-ribosomal peptide). It includes a member from the A-500359 A biosynthetic gene cluster from Streptomyces griseus and appears to be predominantly found in bacteria [[cite:PUB00098866]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00098866":{"PMID":19478828,"ISBN":null,"volume":"62","issue":"6","year":2009,"title":"Identification of the biosynthetic gene cluster of A-500359s in Streptomyces griseus SANK60196.","URL":null,"raw_pages":"325-32","medline_journal":"J Antibiot (Tokyo)","ISO_journal":"J Antibiot (Tokyo)","authors":["Funabashi M","Nonaka K","Yada C","Hosobuchi M","Masuda N","Shibata T","Van Lanen SG."],"DOI_URL":null},"PUB00098776":{"PMID":32101166,"ISBN":null,"volume":"9","issue":null,"year":2020,"title":"Highly regulated, diversifying NTP-dependent biological conflict systems with implications for the emergence of multicellularity.","URL":null,"raw_pages":null,"medline_journal":"Elife","ISO_journal":"Elife","authors":["Kaur G","Burroughs AM","Iyer LM","Aravind L."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":7,"interactions":0,"matches":1208,"pathways":0,"proteins":1203,"proteomes":901,"sets":0,"structural_models":{"alphafold":563},"structures":0,"taxa":1361},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":62,"alignment:full":530},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}