This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000663) is described by MIBiG as an example of the following biosynthetic class, terpene. It includes a member from the hopene biosynthetic gene cluster from Streptomyces coelicolor A3(2) and appears to be predominantly found in actinobacteria [[cite:PUB00098991],[cite:PUB00098992]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00098991":{"PMID":12000953,"ISBN":null,"volume":"417","issue":"6885","year":2002,"title":"Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).","URL":null,"raw_pages":"141-7","medline_journal":"Nature","ISO_journal":"Nature","authors":["Bentley SD","Chater KF","Cerdeno-Tarraga AM","Challis GL","Thomson NR","James KD","Harris DE","Quail MA","Kieser H","Harper D","Bateman A","Brown S","Chandra G","Chen CW","Collins M","Cronin A","Fraser A","Goble A","Hidalgo J","Hornsby T","Howarth S","Huang CH","Kieser T","Larke L","Murphy L","Oliver K","O'Neil S","Rabbinowitsch E","Rajandream MA","Rutherford K","Rutter S","Seeger K","Saunders D","Sharp S","Squares R","Squares S","Taylor K","Warren T","Wietzorrek A","Woodward J","Barrell BG","Parkhill J","Hopwood DA."],"DOI_URL":null},"PUB00098992":{"PMID":8843436,"ISBN":null,"volume":"21","issue":"1","year":1996,"title":"A set of ordered cosmids and a detailed genetic and physical map for the 8 Mb Streptomyces coelicolor A3(2) chromosome.","URL":null,"raw_pages":"77-96","medline_journal":"Mol Microbiol","ISO_journal":"Mol Microbiol","authors":["Redenbach M","Kieser HM","Denapaite D","Eichner A","Cullum J","Kinashi H","Hopwood DA."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":959,"pathways":0,"proteins":959,"proteomes":734,"sets":0,"structural_models":{"alphafold":354},"structures":0,"taxa":781},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":60,"alignment:full":371},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}