This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000069) is described by MIBiG as an example of the following biosynthetic class, polyketide. It includes a member from the gephyronic acid biosynthetic gene cluster from Archangium violaceum Cb vi76 and appears to be predominantly found in bacteria [[cite:PUB00099412]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00099412":{"PMID":24298873,"ISBN":null,"volume":"76","issue":"12","year":2013,"title":"Elucidation of gephyronic acid biosynthetic pathway revealed unexpected SAM-dependent methylations.","URL":null,"raw_pages":"2269-76","medline_journal":"J Nat Prod","ISO_journal":"J Nat Prod","authors":["Young J","Stevens DC","Carmichael R","Tan J","Rachid S","Boddy CN","Muller R","Taylor RE."],"DOI_URL":null}},"set_info":{"accession":"CL0020","name":"TPR"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":10,"pathways":0,"proteins":10,"proteomes":9,"sets":1,"structural_models":{"alphafold":3},"structures":0,"taxa":22},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":2,"alignment:full":4},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}