This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000222) is described by MIBiG as an example of the following biosynthetic class, polyketide. It includes a member from the FD-594 biosynthetic gene cluster from Streptomyces sp. TA-0256 and it appears to be predominantly found in actinobacteria [[cite:PUB00099415]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00099415":{"PMID":21102601,"ISBN":null,"volume":"64","issue":"1","year":2011,"title":"Cloning of the biosynthetic gene cluster for naphthoxanthene antibiotic FD-594 from Streptomyces sp. TA-0256.","URL":null,"raw_pages":"123-32","medline_journal":"J Antibiot (Tokyo)","ISO_journal":"J Antibiot (Tokyo)","authors":["Kudo F","Yonezawa T","Komatsubara A","Mizoue K","Eguchi T."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":760,"pathways":0,"proteins":759,"proteomes":751,"sets":0,"structural_models":{"alphafold":319},"structures":0,"taxa":796},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":49,"alignment:full":360},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}