This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000847) is described by MIBiG as an example of the following biosynthetic class, other (unspecified). It includes a member from the thienamycin biosynthetic gene cluster from Streptomyces cattleya and it appears to be predominantly found in actinobacteria [[cite:PUB00083660]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00083660":{"PMID":12725858,"ISBN":null,"volume":"10","issue":"4","year":2003,"title":"The biosynthetic gene cluster for the beta-lactam carbapenem thienamycin in Streptomyces cattleya.","URL":null,"raw_pages":"301-11","medline_journal":"Chem Biol","ISO_journal":"Chem. Biol.","authors":["Nunez LE","Mendez C","Brana AF","Blanco G","Salas JA."],"DOI_URL":"http://dx.doi.org/10.1016/S1074-5521(03)00069-3"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":3,"interactions":0,"matches":606,"pathways":0,"proteins":606,"proteomes":584,"sets":0,"structural_models":{"alphafold":313},"structures":0,"taxa":787},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":52,"alignment:full":265},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}