This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001796) is described by MIBiG as an example of the following biosynthetic class, NRP (non-ribosomal peptide). It includes a member from the tauramamide biosynthetic gene cluster from Brevibacillus laterosporus DSM 25 and appears to be predominantly found in bacteria [[cite:PUB00098905]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00098905":{"PMID":27694801,"ISBN":null,"volume":"12","issue":"12","year":2016,"title":"Polyketide and nonribosomal peptide retro-biosynthesis and global gene cluster matching.","URL":null,"raw_pages":"1007-1014","medline_journal":"Nat Chem Biol","ISO_journal":"Nat Chem Biol","authors":["Dejong CA","Chen GM","Li H","Johnston CW","Edwards MR","Rees PN","Skinnider MA","Webster AL","Magarvey NA."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":56,"pathways":0,"proteins":56,"proteomes":55,"sets":0,"structural_models":{"alphafold":31},"structures":0,"taxa":124},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":11,"alignment:full":20},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}