This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001905) is described by MIBiG as an example of the following biosynthetic class, polyketide. This family includes a protein from the violapyrone B biosynthetic gene cluster from Streptomyces somaliensis and appears to be predominantly found in Actinobacteria and Caudovirale bacteriophages [[cite:PUB00098956]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00098956":{"PMID":29650021,"ISBN":null,"volume":"17","issue":"1","year":2018,"title":"Overexpression of a type III PKS gene affording novel violapyrones with enhanced anti-influenza A virus activity.","URL":null,"raw_pages":"61","medline_journal":"Microb Cell Fact","ISO_journal":"Microb Cell Fact","authors":["Hou L","Huang H","Li H","Wang S","Ju J","Li W."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":47,"pathways":0,"proteins":47,"proteomes":47,"sets":0,"structural_models":{"alphafold":11},"structures":0,"taxa":127},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":5,"alignment:full":30},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}