This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC00001735) is described by MIBiG as an example of the following biosynthetic class, other. This family includes a protein from the pentostatine biosynthetic gene cluster from Streptomyces antibioticus and appears to be predominantly found in Streptomyces [[cite:PUB00098953]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00098953":{"PMID":28111097,"ISBN":null,"volume":"24","issue":"2","year":2017,"title":"An Unusual Protector-Protege Strategy for the Biosynthesis of Purine Nucleoside Antibiotics.","URL":null,"raw_pages":"171-181","medline_journal":"Cell Chem Biol","ISO_journal":"Cell Chem Biol","authors":["Wu P","Wan D","Xu G","Wang G","Ma H","Wang T","Gao Y","Qi J","Chen X","Zhu J","Li YQ","Deng Z","Chen W."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":3,"interactions":0,"matches":417,"pathways":0,"proteins":417,"proteomes":332,"sets":0,"structural_models":{"alphafold":151},"structures":0,"taxa":402},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":24,"alignment:full":171},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}