{"metadata":{"accession":"PF19557","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR045725","hierarchy":null,"name":{"name":"BrxC/PglY, N-terminal domain","short":"BrxC-PglY_N"},"description":[{"text":"<p>This entry (ex DUF6079) represents the P-loop domain at the N-terminal in Probable ATP-binding protein BrxC and ATPase pglY. BrxC is a core protein of a type 1 BREX system, which provides immunity against bacteriophage. The ATPase PglY is part of a type 2 BREX system, which provides immunity against bacteriophage infections [[cite:PUB00093365],[cite:PUB00161155],[cite:PUB00151239],[cite:PUB00105105]]. PglY hydrolyses ATP but not other nucleotides, and its activity is inhibited by the non-hydrolysable ATP analogue 5-adenylyl beta,gamma-imidodiphosphate.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00161155":{"PMID":7642495,"ISBN":null,"volume":"177","issue":"16","year":1995,"title":"Two genes involved in the phase-variable phi C31 resistance mechanism of Streptomyces coelicolor A3(2).","URL":null,"raw_pages":"4681-9","medline_journal":"J Bacteriol","ISO_journal":"J Bacteriol","authors":["Bedford DJ","Laity C","Buttner MJ."],"DOI_URL":"https://doi.org/10.1128/jb.177.16.4681-4689.1995"},"PUB00105105":{"PMID":25592393,"ISBN":null,"volume":"477","issue":null,"year":2015,"title":"The phage growth limitation system in Streptomyces coelicolor A(3)2 is a toxin/antitoxin system, comprising enzymes with DNA methyltransferase, protein kinase and ATPase activity.","URL":null,"raw_pages":"100-109","medline_journal":"Virology","ISO_journal":"Virology","authors":["Hoskisson PA","Sumby P","Smith MCM."],"DOI_URL":null},"PUB00151239":{"PMID":11972785,"ISBN":null,"volume":"44","issue":"2","year":2002,"title":"Genetics of the phage growth limitation (Pgl) system of Streptomyces coelicolor A3(2).","URL":null,"raw_pages":"489-500","medline_journal":"Mol Microbiol","ISO_journal":"Mol Microbiol","authors":["Sumby P","Smith MC."],"DOI_URL":"https://doi.org/10.1046/j.1365-2958.2002.02896.x"},"PUB00093365":{"PMID":25452498,"ISBN":null,"volume":"34","issue":"2","year":2015,"title":"BREX is a novel phage resistance system widespread in microbial genomes.","URL":null,"raw_pages":"169-83","medline_journal":"EMBO J","ISO_journal":"EMBO J.","authors":["Goldfarb T","Sberro H","Weinstock E","Cohen O","Doron S","Charpak-Amikam Y","Afik S","Ofir G","Sorek R."],"DOI_URL":null}},"set_info":{"accession":"CL0023","name":"P-loop_NTPase"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":34,"interactions":0,"matches":1899,"pathways":0,"proteins":1880,"proteomes":1736,"sets":1,"structural_models":{"alphafold":1075},"structures":3,"taxa":3488},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":8,"alignment:full":990},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}