This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001804) is described by MIBiG as an example of the following biosynthetic class, polyketide. This family includes a protein from the tiancimycin biosynthetic gene cluster from Streptomyces sp. CB03234 and appears to be predominantly found in bacteria [[cite:PUB00098949]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00098949":{"PMID":27999165,"ISBN":null,"volume":"7","issue":"6","year":2016,"title":"Strain Prioritization and Genome Mining for Enediyne Natural Products.","URL":null,"raw_pages":null,"medline_journal":"mBio","ISO_journal":"mBio","authors":["Yan X","Ge H","Huang T","Hindra","Yang D","Teng Q","Crnovcic I","Li X","Rudolf JD","Lohman JR","Gansemans Y","Zhu X","Huang Y","Zhao LX","Jiang Y","Van Nieuwerburgh F","Rader C","Duan Y","Shen B."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":61,"pathways":0,"proteins":61,"proteomes":59,"sets":0,"structural_models":{"alphafold":32},"structures":1,"taxa":131},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":5,"alignment:full":28},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"6ubl","name":"Structure of DynF from the Dynemicin Biosynthesis Pathway of Micromonospora chersina"}}}