This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001769) is described by MIBiG as an example of the following biosynthetic class, polyketide. This family includes a protein from the family saquayamycin A biosynthetic gene cluster from Streptomyces sp. and appears to be predominantly found in Actinobacteria [[cite:PUB00098947]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00098947":{"PMID":28892347,"ISBN":null,"volume":"12","issue":"10","year":2017,"title":"Two Cooperative Glycosyltransferases Are Responsible for the Sugar Diversity of Saquayamycins Isolated from Streptomyces sp. KY 40-1.","URL":null,"raw_pages":"2529-2534","medline_journal":"ACS Chem Biol","ISO_journal":"ACS Chem Biol","authors":["Salem SM","Weidenbach S","Rohr J."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":6,"interactions":0,"matches":2469,"pathways":0,"proteins":2469,"proteomes":1521,"sets":0,"structural_models":{"alphafold":1450},"structures":0,"taxa":2059},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":86,"alignment:full":1056},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}