{"metadata":{"accession":"PF19543","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR045711","hierarchy":null,"name":{"name":"Glycoside hydrolase 123, N-terminal domain","short":"GH123_N"},"description":[{"text":"<p>This domain is found at the N-terminal end of protein members of the glycoside hydrolase family 123, including N-acetylgalactosaminidase from Clostridium perfringens. This enzyme removes specific terminal N-D-acetylgalactosamine from glycosphingolipids. This domain folds into a twisted beta-sandwich that consists of two 5-stranded beta-sheets, two small beta-strands and four small alpha-helices [[cite:PUB00100654]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00151590":{"PMID":27546776,"ISBN":null,"volume":"52","issue":"74","year":2016,"title":"Structural and mechanistic insights into a Bacteroides vulgatus retaining N-acetyl-β-galactosaminidase that uses neighbouring group participation.","URL":null,"raw_pages":"11096-9","medline_journal":"Chem Commun (Camb)","ISO_journal":"Chem Commun (Camb)","authors":["Roth C","Petricevic M","John A","Goddard-Borger ED","Davies GJ","Williams SJ."],"DOI_URL":null},"PUB00100654":{"PMID":27038508,"ISBN":null,"volume":"428","issue":"16","year":2016,"title":"The Details of Glycolipid Glycan Hydrolysis by the Structural Analysis of a Family 123 Glycoside Hydrolase from Clostridium perfringens.","URL":null,"raw_pages":"3253-3265","medline_journal":"J Mol Biol","ISO_journal":"J Mol Biol","authors":["Noach I","Pluvinage B","Laurie C","Abe KT","Alteen MG","Vocadlo DJ","Boraston AB."],"DOI_URL":null}},"set_info":{"accession":"CL0159","name":"E-set"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":8,"interactions":0,"matches":306,"pathways":0,"proteins":306,"proteomes":271,"sets":1,"structural_models":{"alphafold":189},"structures":0,"taxa":442},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":38,"alignment:full":163},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}