{"metadata":{"accession":"PF19535","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR045702","hierarchy":null,"name":{"name":"Family of unknown function (DUF6060)","short":"DUF6060"},"description":[{"text":"<p>This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001035) is described by MIBiG as an example of the following biosynthetic classes, NRP (non-ribosomal peptide),  polyketide and other (Aminocoumarin). This family includes a  protein from the pneumocandin B0 biosynthetic gene cluster from Glarea lozoyensis ATCC 20868 and appear to be predominantly found in fungi [[cite:PUB00098936],[cite:PUB00098937]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00098937":{"PMID":25879325,"ISBN":null,"volume":"10","issue":"7","year":2015,"title":"Genetic Manipulation of the Pneumocandin Biosynthetic Pathway for Generation of Analogues and Evaluation of Their Antifungal Activity.","URL":null,"raw_pages":"1702-10","medline_journal":"ACS Chem Biol","ISO_journal":"ACS Chem Biol","authors":["Li Y","Chen L","Yue Q","Liu X","An Z","Bills GF."],"DOI_URL":null},"PUB00098936":{"PMID":23688303,"ISBN":null,"volume":"14","issue":null,"year":2013,"title":"Genomics-driven discovery of the pneumocandin biosynthetic gene cluster in the fungus Glarea lozoyensis.","URL":null,"raw_pages":"339","medline_journal":"BMC Genomics","ISO_journal":"BMC Genomics","authors":["Chen L","Yue Q","Zhang X","Xiang M","Wang C","Li S","Che Y","Ortiz-Lopez FJ","Bills GF","Liu X","An Z."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":3,"interactions":0,"matches":469,"pathways":0,"proteins":469,"proteomes":292,"sets":0,"structural_models":{"alphafold":354},"structures":0,"taxa":673},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":25,"alignment:full":337},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}