This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001101) is described by MIBiG as an example of the following biosynthetic classes, NRP and Polyketide (Macrolide). This family includes a protein from the leinamycin biosynthetic gene cluster from Streptomyces atroolivaceus and appears to be predominantly found in Actinobacteria [[cite:PUB00099409]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00099409":{"PMID":12446651,"ISBN":null,"volume":"184","issue":"24","year":2002,"title":"Identification and localization of the gene cluster encoding biosynthesis of the antitumor macrolactam leinamycin in Streptomyces atroolivaceus S-140.","URL":null,"raw_pages":"7013-24","medline_journal":"J Bacteriol","ISO_journal":"J Bacteriol","authors":["Cheng YQ","Tang GL","Shen B."],"DOI_URL":null}},"set_info":{"accession":"CL0032","name":"Dim_A_B_barrel"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":104,"pathways":0,"proteins":102,"proteomes":46,"sets":1,"structural_models":{"alphafold":52},"structures":0,"taxa":105},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":14,"alignment:full":77},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}