{"metadata":{"accession":"PF19493","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR045794","hierarchy":null,"name":{"name":"Trypsin-co-occurring domain 1","short":"Trypco1"},"description":[{"text":"<p>Trypsin-like peptidase effector in the classical NTP-dependent ternary system (vWA-MoxR-VMAP) frequently co-occurs with one of two proteins (Trypco1 or Trypco2) which are mostly mutually exclusively [[cite:PUB00098776]].  This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000703) is described by MIBiG as an example of the following biosynthetic class, saccharide, in particular the  kanamycin biosynthetic gene cluster from Streptomyces kanamyceticus  [[cite:PUB00098882]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00098882":{"PMID":16766657,"ISBN":null,"volume":"103","issue":"25","year":2006,"title":"Amplification of the entire kanamycin biosynthetic gene cluster during empirical strain improvement of Streptomyces kanamyceticus.","URL":null,"raw_pages":"9661-6","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc Natl Acad Sci U S A","authors":["Yanai K","Murakami T","Bibb M."],"DOI_URL":null},"PUB00098776":{"PMID":32101166,"ISBN":null,"volume":"9","issue":null,"year":2020,"title":"Highly regulated, diversifying NTP-dependent biological conflict systems with implications for the emergence of multicellularity.","URL":null,"raw_pages":null,"medline_journal":"Elife","ISO_journal":"Elife","authors":["Kaur G","Burroughs AM","Iyer LM","Aravind L."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":8,"interactions":0,"matches":2475,"pathways":0,"proteins":2475,"proteomes":1433,"sets":0,"structural_models":{"alphafold":1210},"structures":0,"taxa":2137},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":211,"alignment:full":1249},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}