This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001387) is described by MIBiG as an example of the following biosynthetic class, other (unspecified). This family includes a protein from the nucleocidin biosynthetic gene cluster from Streptomyces calvus and appear to be predominantly found in Actinobacteria [[cite:PUB00099448]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00099448":{"PMID":26374477,"ISBN":null,"volume":"16","issue":"17","year":2015,"title":"Biosynthesis of the Fluorinated Natural Product Nucleocidin in Streptomyces calvus Is Dependent on the bldA-Specified Leu-tRNA(UUA) Molecule.","URL":null,"raw_pages":"2498-506","medline_journal":"Chembiochem","ISO_journal":"Chembiochem","authors":["Zhu XM","Hackl S","Thaker MN","Kalan L","Weber C","Urgast DS","Krupp EM","Brewer A","Vanner S","Szawiola A","Yim G","Feldmann J","Bechthold A","Wright GD","Zechel DL."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":50,"pathways":0,"proteins":50,"proteomes":49,"sets":0,"structural_models":{"alphafold":28},"structures":0,"taxa":101},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":7,"alignment:full":28},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}