This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001992) is described by MIBiG as an example of the following biosynthetic class, other (unspecified). This family includes a protein from the thioguanine biosynthetic gene cluster from Erwinia amylovora CFBP1430 [[cite:PUB00099374]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00099374":{"PMID":29947149,"ISBN":null,"volume":"57","issue":"36","year":2018,"title":"Enzymatic Thioamide Formation in a Bacterial Antimetabolite Pathway.","URL":null,"raw_pages":"11574-11578","medline_journal":"Angew Chem Int Ed Engl","ISO_journal":"Angew Chem Int Ed Engl","authors":["Litomska A","Ishida K","Dunbar KL","Boettger M","Coyne S","Hertweck C."],"DOI_URL":null}},"set_info":{"accession":"CL0061","name":"PLP_aminotran"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":86,"pathways":0,"proteins":86,"proteomes":85,"sets":1,"structural_models":{"alphafold":51},"structures":1,"taxa":146},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":5,"alignment:full":23},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}