{"metadata":{"accession":"PF19486","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR046064","hierarchy":null,"name":{"name":"Family of unknown function (DUF6022)","short":"DUF6022"},"description":[{"text":"<p>This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000693) is described by MIBiG as an example of the following biosynthetic class, saccharide. This family includes a  protein from the butirosin A biosynthetic gene cluster from Bacillus  circulans and appears to be predominantly found in Bacilli [[cite:PUB00008404],[cite:PUB00076502]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00008404":{"PMID":11132962,"ISBN":null,"volume":"53","issue":"10","year":2000,"title":"Butirosin-biosynthetic gene cluster from Bacillus circulans.","URL":null,"raw_pages":"1158-67","medline_journal":"J Antibiot (Tokyo)","ISO_journal":"J. Antibiot.","authors":["Ota Y","Tamegai H","Kudo F","Kuriki H","Koike-Takeshita A","Eguchi T","Kakinuma K."],"DOI_URL":null},"PUB00076502":{"PMID":16156513,"ISBN":null,"volume":"58","issue":"6","year":2005,"title":"Extended sequence and functional analysis of the butirosin biosynthetic gene cluster in Bacillus circulans SANK 72073.","URL":null,"raw_pages":"373-9","medline_journal":"J Antibiot (Tokyo)","ISO_journal":"J. Antibiot.","authors":["Kudo F","Numakura M","Tamegai H","Yamamoto H","Eguchi T","Kakinuma K."],"DOI_URL":"http://dx.doi.org/10.1038/ja.2005.47"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":180,"pathways":0,"proteins":180,"proteomes":161,"sets":0,"structural_models":{"alphafold":101},"structures":0,"taxa":293},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":23,"alignment:full":93},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}