This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000399) is described by MIBiG as an example of the following biosynthetic class, NRP (non-ribosomal peptide). This family includes a protein from the orfamide A biosynthetic gene cluster from Pseudomonas protegens Pf-5 and appears to be predominantly found in Pseudomonadaceae [[cite:PUB00099440]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00099440":{"PMID":17254952,"ISBN":null,"volume":"14","issue":"1","year":2007,"title":"The genomisotopic approach: a systematic method to isolate products of orphan biosynthetic gene clusters.","URL":null,"raw_pages":"53-63","medline_journal":"Chem Biol","ISO_journal":"Chem Biol","authors":["Gross H","Stockwell VO","Henkels MD","Nowak-Thompson B","Loper JE","Gerwick WH."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":225,"pathways":0,"proteins":225,"proteomes":224,"sets":0,"structural_models":{"alphafold":93},"structures":0,"taxa":256},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":4,"alignment:full":15},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}