This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000332) is described by MIBiG as an example of the following biosynthetic class, NRP (non-ribosomal peptide). This family includes a protein from the cyanopeptolin biosynthetic gene cluster from Microcystis sp. NIVA-CYA 172/5 and appears to be predominantly found in Cyanobacteria [[cite:PUB00099392]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00099392":{"PMID":17464052,"ISBN":null,"volume":"153","issue":"Pt 5","year":2007,"title":"Structural analysis of a non-ribosomal halogenated cyclic peptide and its putative operon from Microcystis: implications for evolution of cyanopeptolins.","URL":null,"raw_pages":"1382-1393","medline_journal":"Microbiology (Reading)","ISO_journal":"Microbiology (Reading)","authors":["Tooming-Klunderud A","Rohrlack T","Shalchian-Tabrizi K","Kristensen T","Jakobsen KS."],"DOI_URL":null}},"set_info":{"accession":"CL0126","name":"Peptidase_MA"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":14,"pathways":0,"proteins":14,"proteomes":13,"sets":1,"structural_models":{"alphafold":11},"structures":0,"taxa":51},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":3,"alignment:full":8},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}