{"metadata":{"accession":"PF19476","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR046055","hierarchy":null,"name":{"name":"Family of unknown function (DUF6013)","short":"DUF6013"},"description":[{"text":"<p>This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001120) is described by MIBiG as an example of the following biosynthetic classes, NRP (non-ribosomal peptide) and polyketide. This family includes a protein from the Burkholderia acid biosynthetic gene cluster from Burkholderia thailandensis E264 and appears to be predominantly found in Burkholderiaceae [[cite:PUB00099376],[cite:PUB00099398]]</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00099376":{"PMID":23055407,"ISBN":null,"volume":"51","issue":"46","year":2012,"title":"Genomics-driven discovery of burkholderic acid, a noncanonical, cryptic polyketide from human pathogenic Burkholderia species.","URL":null,"raw_pages":"11611-5","medline_journal":"Angew Chem Int Ed Engl","ISO_journal":"Angew Chem Int Ed Engl","authors":["Franke J","Ishida K","Hertweck C."],"DOI_URL":null},"PUB00099398":{"PMID":22765305,"ISBN":null,"volume":"134","issue":"32","year":2012,"title":"Malleilactone, a polyketide synthase-derived virulence factor encoded by the cryptic secondary metabolome of Burkholderia pseudomallei group pathogens.","URL":null,"raw_pages":"13192-5","medline_journal":"J Am Chem Soc","ISO_journal":"J Am Chem Soc","authors":["Biggins JB","Ternei MA","Brady SF."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":180,"pathways":0,"proteins":180,"proteomes":180,"sets":0,"structural_models":{"alphafold":131},"structures":0,"taxa":212},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":31,"alignment:full":61},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}