{"metadata":{"accession":"PF19472","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR046051","hierarchy":null,"name":{"name":"Family of unknown function (DUF6009)","short":"DUF6009"},"description":[{"text":"<p>This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000965) is described by MIBiG as an example of the following biosynthetic class, polyketide. This family includes a  protein from the C-1027 biosynthetic gene cluster from  Streptomyces globisporus [[cite:PUB00099378],[cite:PUB00099425]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00099425":{"PMID":12183628,"ISBN":null,"volume":"297","issue":"5584","year":2002,"title":"Biosynthesis of the enediyne antitumor antibiotic C-1027.","URL":null,"raw_pages":"1170-3","medline_journal":"Science","ISO_journal":"Science","authors":["Liu W","Christenson SD","Standage S","Shen B."],"DOI_URL":null},"PUB00099378":{"PMID":10639366,"ISBN":null,"volume":"44","issue":"2","year":2000,"title":"Genes for production of the enediyne antitumor antibiotic C-1027 in Streptomyces globisporus are clustered with the cagA gene that encodes the C-1027 apoprotein.","URL":null,"raw_pages":"382-92","medline_journal":"Antimicrob Agents Chemother","ISO_journal":"Antimicrob Agents Chemother","authors":["Liu W","Shen B."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":325,"pathways":0,"proteins":325,"proteomes":220,"sets":0,"structural_models":{"alphafold":136},"structures":0,"taxa":293},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":14,"alignment:full":176},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}