{"metadata":{"accession":"PF19469","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR046048","hierarchy":null,"name":{"name":"Family of unknown function (DUF6006)","short":"DUF6006"},"description":[{"text":"<p>This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001016) is described by MIBiG as an example of the following biosynthetic classes, NRP (non-ribosomal peptide) and polyketide. This family includes a protein from then microcystin  biosynthetic gene cluster from Anabaena sp. 90 [[cite:PUB00099379]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00099379":{"PMID":14766543,"ISBN":null,"volume":"70","issue":"2","year":2004,"title":"Genes coding for hepatotoxic heptapeptides (microcystins) in the cyanobacterium Anabaena strain 90.","URL":null,"raw_pages":"686-92","medline_journal":"Appl Environ Microbiol","ISO_journal":"Appl Environ Microbiol","authors":["Rouhiainen L","Vakkilainen T","Siemer BL","Buikema W","Haselkorn R","Sivonen K."],"DOI_URL":null},"PUB00152593":{"PMID":17163649,"ISBN":null,"volume":"1","issue":"2","year":2006,"title":"Structural characterization of in vitro and in vivo intermediates on the loading module of microcystin synthetase.","URL":null,"raw_pages":"93-102","medline_journal":"ACS Chem Biol","ISO_journal":"ACS Chem Biol","authors":["Hicks LM","Moffitt MC","Beer LL","Moore BS","Kelleher NL."],"DOI_URL":"https://doi.org/10.1021/cb500007v"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":42,"pathways":0,"proteins":42,"proteomes":40,"sets":0,"structural_models":{"alphafold":27},"structures":0,"taxa":140},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":5,"alignment:full":29},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}