This entry represents the N-terminal domain of uncharacterised bacterial proteins. A member of a biosynthetic gene cluster (BGC). (BGC0000942) is described by MIBiG as an example of the following biosynthetic class, other (unspecified). This family includes a protein from the petrobactin biosynthetic gene cluster from Bacillus anthracis str. Ames [[cite:PUB00099423]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00099423":{"PMID":14756782,"ISBN":null,"volume":"51","issue":"2","year":2004,"title":"Bacillus anthracis requires siderophore biosynthesis for growth in macrophages and mouse virulence.","URL":null,"raw_pages":"407-17","medline_journal":"Mol Microbiol","ISO_journal":"Mol Microbiol","authors":["Cendrowski S","MacArthur W","Hanna P."],"DOI_URL":null}},"set_info":{"accession":"CL0125","name":"Peptidase_CA"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":4,"interactions":0,"matches":255,"pathways":0,"proteins":255,"proteomes":247,"sets":1,"structural_models":{"alphafold":147},"structures":0,"taxa":424},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":34,"alignment:full":106},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}