This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000033) is described by MIBiG as an example of the following biosynthetic class, polyketide. This family includes a protein from the calicheamicin biosynthetic gene cluster from Micromonospora echinospora [[cite:PUB00099426]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00099426":{"PMID":12183629,"ISBN":null,"volume":"297","issue":"5584","year":2002,"title":"The calicheamicin gene cluster and its iterative type I enediyne PKS.","URL":null,"raw_pages":"1173-6","medline_journal":"Science","ISO_journal":"Science","authors":["Ahlert J","Shepard E","Lomovskaya N","Zazopoulos E","Staffa A","Bachmann BO","Huang K","Fonstein L","Czisny A","Whitwam RE","Farnet CM","Thorson JS."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":49,"pathways":0,"proteins":49,"proteomes":48,"sets":0,"structural_models":{"alphafold":36},"structures":0,"taxa":85},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":1,"alignment:full":21},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}