This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000100) is described by MIBiG as an example of the following biosynthetic class, polyketide. This family includes a protein from monensin biosynthetic gene cluster from Streptomyces cinnamonensis [[cite:PUB00099424]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00099424":{"PMID":12940979,"ISBN":null,"volume":"49","issue":"5","year":2003,"title":"Analysis of the biosynthetic gene cluster for the polyether antibiotic monensin in Streptomyces cinnamonensis and evidence for the role of monB and monC genes in oxidative cyclization.","URL":null,"raw_pages":"1179-90","medline_journal":"Mol Microbiol","ISO_journal":"Mol Microbiol","authors":["Oliynyk M","Stark CB","Bhatt A","Jones MA","Hughes-Thomas ZA","Wilkinson C","Oliynyk Z","Demydchuk Y","Staunton J","Leadlay PF."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":202,"pathways":0,"proteins":202,"proteomes":193,"sets":0,"structural_models":{"alphafold":80},"structures":0,"taxa":238},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":44,"alignment:full":83},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}