This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000833) is described by MIBiG as an example of the following biosynthetic classes, saccharide and other (unspecified). This family includes a protein from the coumermycin A1 biosynthetic gene cluster from Streptomyces rishiriensis [[cite:PUB00099450]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00099450":{"PMID":18288655,"ISBN":null,"volume":"9","issue":"4","year":2008,"title":"Assembly and heterologous expression of the coumermycin A1 gene cluster and production of new derivatives by genetic engineering.","URL":null,"raw_pages":"603-12","medline_journal":"Chembiochem","ISO_journal":"Chembiochem","authors":["Wolpert M","Heide L","Kammerer B","Gust B."],"DOI_URL":null}},"set_info":{"accession":"CL0063","name":"NADP_Rossmann"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":162,"pathways":0,"proteins":162,"proteomes":158,"sets":1,"structural_models":{"alphafold":91},"structures":0,"taxa":252},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":14,"alignment:full":83},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}