This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000434) is described by MIBiG as an example of the following biosynthetic class, NRP (non-ribosomal peptide). This family includes a protein from the SW-163C biosynthetic gene cluster from Streptomyces sp. SNA15896 [[cite:PUB00083668]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00083668":{"PMID":19514719,"ISBN":null,"volume":"131","issue":"26","year":2009,"title":"Escherichia coli allows efficient modular incorporation of newly isolated quinomycin biosynthetic enzyme into echinomycin biosynthetic pathway for rational design and synthesis of potent antibiotic unnatural natural product.","URL":null,"raw_pages":"9347-53","medline_journal":"J Am Chem Soc","ISO_journal":"J. Am. Chem. Soc.","authors":["Watanabe K","Hotta K","Nakaya M","Praseuth AP","Wang CC","Inada D","Takahashi K","Fukushi E","Oguri H","Oikawa H."],"DOI_URL":"http://dx.doi.org/10.1021/ja902261a"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":4,"interactions":0,"matches":1986,"pathways":0,"proteins":1984,"proteomes":1867,"sets":0,"structural_models":{"alphafold":1180},"structures":0,"taxa":2846},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":275,"alignment:full":986},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}