This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000202) is described by MIBiG as an example of the following biosynthetic class, polyketide. This family contains a protein found in the azicemicin B biosynthetic gene cluster from Kibdelosporangium sp. MJ126-NF4 [[cite:PUB00099399]]. The function of this protein is unknown.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00099399":{"PMID":19928906,"ISBN":null,"volume":"131","issue":"50","year":2009,"title":"Biosynthetic studies of aziridine formation in azicemicins.","URL":null,"raw_pages":"18066-8","medline_journal":"J Am Chem Soc","ISO_journal":"J Am Chem Soc","authors":["Ogasawara Y","Liu HW."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":5,"interactions":0,"matches":2984,"pathways":0,"proteins":2979,"proteomes":1343,"sets":0,"structural_models":{"alphafold":1551},"structures":0,"taxa":1586},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":219,"alignment:full":1243},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}