This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001048) is described by MIBiG as an example of the following biosynthetic classes, NRP (non-ribosomal peptide), polyketide, and saccharide. This family includes a protein in the tallysomycin A biosynthetic gene cluster from Streptoalloteichus hindustanus [[cite:PUB00083679]]. Some members of this family have been annotated as monooxygenase, but this could not be confirmed.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00083679":{"PMID":17216057,"ISBN":null,"volume":"3","issue":"1","year":2007,"title":"The tallysomycin biosynthetic gene cluster from Streptoalloteichus hindustanus E465-94 ATCC 31158 unveiling new insights into the biosynthesis of the bleomycin family of antitumor antibiotics.","URL":null,"raw_pages":"60-74","medline_journal":"Mol Biosyst","ISO_journal":"Mol Biosyst","authors":["Tao M","Wang L","Wendt-Pienkowski E","George NP","Galm U","Zhang G","Coughlin JM","Shen B."],"DOI_URL":"http://dx.doi.org/10.1039/b615284h"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":6,"interactions":0,"matches":606,"pathways":0,"proteins":605,"proteomes":592,"sets":0,"structural_models":{"alphafold":332},"structures":0,"taxa":977},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":88,"alignment:full":305},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}